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Palmitic acid, kahweol, and cafestol are key diterpene compounds in coffee that can activate Phase II detoxification enzymes in the liver, potentially increasing glutathione levels

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Some were then reported removed from Category 2 in 20242026 after their nominations were withdrawn but removal is not an approval, and because they were not placed on Category 1 and are not FDA-approved, many licensed pharmacies still decline to compound them rather than risk enforcement

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