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The time when you will notice significant changes in response to B12 supplementation is when you ask how long B12 takes to work

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SystemsAge was calculated using the methylCIPHER package ( The Intrinsic Capacity epigenetic clock was calculated using code available at DNAmFitAge and additional epigenetic metrics were calculated via TruDiagnostics DNAm Analysis Software, available at no cost for research purposes upon request ( access requires agreement to a standard noncommercial software license for academic, nonprofit research use