Specifically, mitochondrial complex I is believed to be the main component of mitochondria affected in PD as Complex I of the electron transport chain is left vulnerable to oxidative damage (Vali et al., 2007)
The first responding cells are microglia and adult oligodendrocyte precursor cells (OPC), which migrate towards the lesion, with astrocyte responses to follow
Teixeira MI, Lopes CM, Amaral MH, Costa PC
While this effect is minor in a sealed vial over the short term, refrigeration helps keep the preservative where it belongs: in the solution
Importantly, PUFAs, when incorporated into membranes under the catalysis of ACSL4, serve as major substrates for lipid peroxidation during ferroptosis [93, 94]
Antioxidant-Rich Formula