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Revised: Mar 2025 Side Effects for Emgality The following clinically significant adverse reactions are described elsewhere in the labeling: Hypersensitivity Reactions [see CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS ] Hypertension [see WARNINGS AND PRECAUTIONS ] Raynaud's Phenomenon [see WARNINGS AND PRECAUTIONS ] Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in clinical trials of another drug and may not reflect the rates observed in clinical practice

Cotadutide (medi0382), a dual receptor agonist with glucagon-like peptide-1 and glucagon activity, modulates hepatic glycogen and fat content

Some studies suggest GLP-1s may affect the mesolimbic reward system and hippocampus, key brain regions involved in both metabolic regulation and emotional processing (12)

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