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Combined with adequate protein intake (widely recommended at 1.2-1.6g per kg of body weight during GLP-1 protocols) and resistance training, the higher dose ranges may actually preserve lean mass better than lower doses, because the energy deficit is being met predominantly through fat oxidation rather than muscle catabolism
Adequate protein intake, biotin supplementation, and avoiding excessively rapid weight loss (more than 2-3 pounds per week) reduce the risk
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Sikiri, R
Dev Biol Prokaryotes Lower Eukaryotes (2021), 54165
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