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Any disruption along this pathway can lead to deficiency regardless of dietary intake, which is why some patients need supplementation even when they eat B12-rich foods

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B-complex vitamins are your best oral bet, though digestive absorption is only 50-70% versus IV's 100%

AOD-9604 is generally well-tolerated with a favorable safety profile based on clinical research involving approximately 900 participants across six studies

Here is a breakdown: Most people are able to get enough vitamin B12 from their diets, Allen says, so widespread supplementation isn't necessary

Vitamins in Animal and Human Nutrition (2nd ed.)