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Moreover, RNA modifications of mitochondrial rRNA, including m 6,2 A modifications in helix 45 (h45) of 12 S mt-rRNA modified by mitochondrial transcription factor B1 (TFB1M), m 4 C modification at position C840 and m 5 C modification at position C842 of 12S mt-rRNA by METTL17 and m 4 C at position C839 of 12S mt-rRNA by METTL15, dominate the translational function of mitochondria-coding genes that influence mitochondrial respiration and other biological processes [204,205,206]

More recently, the concept of nutrient-stimulated hormone-based therapeutics, involving novel combinations like GLP-1 with other gut hormones such as GIP and glucagon, highlights the growing importance and effectiveness of GLP-1 based therapies in managing these chronic conditions