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FOXO4-DRI (Proxofim) is a synthetic retro-inverso peptide designed to disrupt the interaction between FOXO4 transcription factor and p53

Because of this, its plausible that some patients could experience broader systemic effects, including hormonal or temperature-related symptoms

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As an alternative strategy, bvPLA2 was shown to be effective in slowing the course of Alzheimers disease in transgenic mice

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