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So far, clinical trials havent resulted in regulatory approval, and pharmaceutical companies havent been motivated to invest in further development

2003 May 1;371(Pt 3):887-95

Individuals with autonomically mediated syncope suffer from frequent episodes of fainting or near fainting where the blood pressure drops by 20 mmHg systolic/ 10 mmHg diastolic with upright posture

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Physiological stress exacerbates murine colitis by enhancing proinflammatory cytokine expression that is dependent on IL-18