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Simultaneously, dysregulated metabolism in obesity leads to increased oxidative stressan imbalance between harmful free radicals and the body's antioxidant defenses

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The data indicates that the dual nature of its effects on metabolism is the most effective weight loss medication on the market

Conversely, remaining untreated for obesity during pregnancy carries documented risks: gestational diabetes rates approach 30% in untreated women with obesity, and preeclampsia risk doubles or triples

GLP-1RAs also downregulate the expression of MMPs and tissue inhibitors of MPs (TIMPs) for anti-inflammation [110]