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doi: 10.3389/fphys.2023.1308632 Received 06 October 2023 Accepted 27 November 2023 Published 11 December 2023 Volume 14 - 2023 Edited by Lars Kaestner, Saarland University, Germany Reviewed by Vassilis L

In most diseases, ROS appear to have a direct connection with inflammaging and cell senescence, and oxidative stress and inflammaging increase the aging-related phenotype, and induce and aggravate the inflammatory response, creating a chronic state of systemic inflammation (290297)

Additionally, other factors such as having had gastric bypass surgery or taking antacids long-term can lead to deficiency