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10.1111/j.1432-1033.1984.tb07943.x
NICEs original 30k/QALY threshold was designed to reflect the average NHS opportunity cost (the health that must be foregone when funding the drug)
We also know that if oral contraceptives are taken inconsistently they wont work as welland that losing weight can make you more likely to get pregnant, even if you only miss one dose of your birth control pills
These results indicate that the increased amount of non-12-OH FXR-antagonistic BAs consequent to the decrease in CYP8B1 expression after T3 treatment potentiates GLP-1 production by deactivating the intestinal FXR, thereby improving glucose homeostasis via the augmentation of insulin secretion
1,3 Wait a bit after eating to exercise as well, as exercising after eating a meal can lead to upset stomach and nausea
