As the dominant G-actin sequestering protein in mammalian cells, TB-500 binds globular actin with high affinity (Kd ~0.5 M) through a sophisticated triple-contact mechanism involving Lys-3, Lys-18, and Lys-38 residues, preventing spontaneous actin polymerization while maintaining a readily mobilizable reservoir for rapid cytoskeletal reorganization
Glutathione S-transferase polymorphisms and risk of second primary malignancy after index squamous cell carcinoma of the head and neck
The Expanding GLP-1 Drug Pipeline UBT251 is just one of many compounds currently being explored in the growing GLP-1 and incretin drug pipeline
Appetite suppression can be profound enough that patients fail to eat adequate protein, risking muscle loss and metabolic complications
When FXR is inhibited, intestinal stem cells generate more L-cells, which produce GLP-1
Drug Products Containing Quinine