Aspiration can lead to several serious complications: Aspiration pneumonitis : Chemical injury to lung tissue from acidic gastric contents, causing inflammation, hypoxemia, and potentially acute respiratory distress syndrome (ARDS) [8] [9] Aspiration pneumonia : Bacterial infection resulting from aspirated material Airway obstruction : Particulate matter blocking airways Prolonged mechanical ventilation : Severe cases may require respiratory support Potential for ICU admission and extended hospital stay if severe aspiration occurs Case reports and observational studies have documented instances of unexpected gastric contents found during endoscopy or anesthesia induction in patients taking GLP-1 receptor agonists who had followed standard fasting protocols
The FDA staff said no
Oh JY, Barrett-Connor E, Rancho Bernardo Study G
(PubMed) Stamp LK, Zhu X, Dalbeth N, Jordan S, Edwards NL, Taylor W
The test program, known as BALANCE, was scheduled to run in Part D through 2031 and would have covered all formulations of Mounjaro, Ozempic, Rybelsus and Wegovy, along with the KwikPen formulation of Foundayo and Zepbound
AOD-9604 is a synthetic copy of that region, plus one extra amino acid for stability