As of now, there have not been direct head-to-head clinical studies comparing retatrutide and tirzepatide
Scenario 3: Want next pregnancy within 12 months Retatrutide may not be appropriate
Your GP is the natural first point of contact and can assess your overall health, calculate your BMI, review any relevant comorbidities, and determine whether you meet the criteria for approved weight management treatments on the NHS or via a referral to a specialist service
Similarly, the highly anticipated EVOKE and EVOKE+ phase 3 trials of oral semaglutide in early Alzheimers disease reported in November 2025 that semaglutide failed to meet its primary endpoints : while it reduced several AD-related biomarkers by up to 10%, these changes did not translate into cognitive or functional benefit ( [72] )
The usual reason to switch is a plateau
The drug labels for Zepbound and Mounjaro mention a risk of thyroid C-cell tumors