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GLP-1 (glucagon-like peptide-1) is an endogenous hormone that plays a crucial role in regulating appetite, blood sugar levels, and digestion

In a healthy body, dietary folate is converted through a series of enzymatic steps into its biologically active form, L-5-methyltetrahydrofolate (L-5-MTHF)

The combination may lead to excessive appetite suppression in some individuals, potentially resulting in inadequate nutritional intake or rapid weight loss that could affect mood stability

While alopecia appears in Wegovy's FDA label at low frequency, hair loss during semaglutide treatment more commonly results from rapid weight loss triggering telogen effluvium rather than direct drug effects

In practice there is often a combination of the two