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This observation supports the view that removing a Leucine plug by mechanical force [1,2, 5] is a key step in ligand-induced activation of Drosophila and vertebrate Notch, and further suggests that the Epsin-mediated pulling force is specifically required to accomplish this step

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Coinfusion of Low-Dose GLP-1 and Glucagon in Man Results in a Reduction in Food Intake

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