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However, the compound became widely available for routine use in the treatment of B12 deficiency in the early 1950s (8)

I suppose That'd get pretty darn expensive and I don't think anybody wants to depend on anything like that the rest of their life period

Here is where the confusion starts

The bioavailability in the portal vein is important, since there are GLP-1 receptors in both the portal vein, and on the membranes of vagal afferent nerve cell in the intestine, which will be accessed by the peptide before it reaches the outer circulation

They are generally not used in children (except certain cases with a doctors recommendation) and are not safe in pregnancy or breastfeeding

Guan et al