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Mechanistic sub-study embedded in an efficacy trial + Incorporate GSM/dryness endpoints (validated questionnaires, clinician assessment, pH) into semaglutide RCTs or pragmatic trials, with pre-specified subgroup analyses by menopausal status and HRT use

A Mendelian randomization study in Frontiers in Endocrinology found that genetically predicted higher insulin resistance was associated with worse cognitive performance, with changes in brain cortical structure mediating part of the effect

This dual mechanism appears to produce even greater effects than GLP-1 alone for many patients

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Here, Sea buckthorn pulp/juice is a well-known natural antioxidant booster that provides several health benefits your body needs

Tryptophan promotes TGF-1induced EMT and fibroblast activation via the mTOR/S6 signaling pathway, exacerbating fibrotic progression [112]