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Alpha-arbutin and beta-arbutin - these molecules are derived from hydroquinone, which is available in prescription only pigmentation treatments in the UK

These noticeable scars can detract from the overall results, leaving the treated area looking less smooth or uneven and potentially causing long-term aesthetic concerns

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However, it should be possible if needed by measurement of gamma-glutamylcysteine synthetase activity or mutational analysis (if the mutation in the family is known) of chorionic villi or cultured amniocytes

PMID 35163773

Key molecular mechanisms include mitochondrial reverse electron transport activation induced by mutant proto-oncogenes KRAS/BRAF [385], oxidative inactivation of DNA repair enzymes leading to mutation accumulation [386], and constitutive activation of NRF2 pathway [387]