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Circulating levels decline with age, from roughly 200 ng/mL at age 20 to about 80 ng/mL by 60. Small split-face human dermatology studies, usually with fewer than 50 participants per arm, report changes in wrinkle depth and skin density
Most GI symptoms are temporary and peak during dose escalations
Most gastrointestinal effects have been observed to diminish with continued exposure and gradual dose titration
If that is you, it is understandably worrying, but in almost all cases it is short-lived and harmless
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