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Achieving target blood pressure and cholesterol levels helps substantially but doesnt eliminate risk entirely

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SGLT2is provide cardio-renal benefits, despite an increase in the risk of DKA and urinary tract infection compared with GLP-1 RA therapy

doi: 10.1155/2015/972891

However, iron overload in patients with hemochromatosis results in excessive PS externalization and calpain activation in RBCs [83]