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In fact, low vitamin D levels have been linked to the onset and progression of neurological disorders such as migraine headache, diabetic neuropathy, multiple sclerosis, Alzheimer disease, and Parkinson disease

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However, consumers should exercise caution and consult healthcare providers before using such supplements, as their safety and efficacy might not be well-established

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Reduced MTHFR activity reduced methionine regeneration reduced SAM production reduced methylation capacity across all SAM-dependent methyltransferase reactions consequences that propagate through epigenetics, neurotransmitter metabolism, creatine synthesis, phosphatidylcholine production, and the broader biochemistry that SAM sustains