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Phosphorylated Smad2 associates with STAT3 to facilitate Th17 cell polarization, whereas unphosphorylated Smad3 interacts with STAT3 to inhibit Th17 cell differentiation
Direct Receptor-Mediated Effects : While preclinical studies suggest GLP-1 receptors may be present in bone tissue, the clinical relevance of direct receptor activation in human bone cells remains uncertain and controversial
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C: mmol/glutathione (mg/dl)
Wnt pathway inhibitors, including WNT974 (NCT02278133) and vantictumab (NCT01973309), have been evaluated in BRAF-mutant colorectal cancer and metastatic breast cancer, respectively
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