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Astrocytes release ApoE-containing exosomes to transport keto bodies, cholesterol, and phospholipids between glia and neurons to supply them with energy
With weekly injections, blood levels build up over about 4 weeks before reaching steady state at roughly 1.6 a single dose
Your surgeon, anesthesiologist, and prescribing clinician should determine whether any temporary medication changes are necessary based on your procedure, gastrointestinal symptoms, stage of treatment (including dose escalation), and overall health
5 Department of Medicine and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Phase 2 trial data (Jastreboff et al., NEJM, 2023) showed mean body weight reductions of approximately 24% at 48 weeks with the highest dose, with no clear plateau observed
PloS One 13, e0193473
