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Chem Rev (2013) 113(7):463379.10.1021/cr300163e 9 TruongTHCarrollKS

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The real mechanism (lowering the stress hormone cortisol that impairs the prefrontal cortex and hippocampus, plus a GABA-mimetic and mild acetylcholinesterase action)

For example, hepatotoxicity may be amplified not only by 17-alkylated oral steroids but also by concomitant use of other hepatically metabolized agents, alcohol, contaminated or counterfeit products, and high-dose supplements (93, 95)

Loss of EEFSEC function causes specific hypoplasia of the midbrain and hindbrain without impairing global somatic growth with structural defects that directly correlate with locomotor impairment and blunted escape responses, mirroring the human phenotype

Melatonin counteracts lipopolysaccharide-induced expression and activity of mitochondrial nitric oxide synthase in rats