Like other antiepileptic drugs, Topiramate may cause suicidal thoughts or actions in a very small number of people, about 1 in 500
This is an observational study, not a randomised trial, and the authors caution against basing treatment recommendations on these data, without further confirmation
The dose is gradually increased under the guidance of the healthcare provider until the maximum tolerable dose is reached
[6] Muttenthaler M, et al
201,202 Due to the limitations of clinical studies, the evaluation of drugs needs to rely on some new examination methods, such as imaging
While there have been new entrants to the handful of drugs in this class, the class itself is actually not new: the first, Byetta, received FDA approval in 2005