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Semaglutide (brand name Wegovy) is a medication that mirrors a natural hormone called glucagon-like peptide-1 (GLP-1), which is responsible for regulating your appetite

Food and Drug Administration (FDA) database from 2004 to 2009 reported increased risks of pancreatic and thyroid cancer associated with the GLP-1 receptor agonist (GLP-1RA) exenatide compared to other therapies [8]

And studies have found that many people who take them for diabetes or weight loss experience surprising side effects

The mechanism of action involves binding to GLP-1 receptors found throughout the body, particularly in the pancreas, brain, and gastrointestinal tract

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Standard dose escalation The typical semaglutide dose escalation schedule follows this pattern: Weeks 1-4: 0.25mg once weekly Weeks 5-8: 0.5mg once weekly Weeks 9-12: 1.0mg once weekly Weeks 13-16: 1.7mg once weekly Week 17 onward: 2.4mg once weekly (maintenance dose for weight management) This escalation exists for a reason