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It occurs exclusively in the cytosol, where glutamate cysteine ligase (GCL) and glutathione synthetase (GS) perform their function
Statistical analysis Data were visualized and statistical analyses performed using Prism 9.5.1 software (Graph Pad)
Nicotinamide sensitizes human breast cancer cells to the cytotoxic effects of radiation and cisplatin
Glutamine starvation inhibits M2 polarization but not M1 polarization by suppressing UDP-GlcNAc biosynthesis and N-glycosylation of M2-related proteins such as Relm, CD206, and CD301 141
One of the most studied effects is angiogenesis , or the formation of new blood vessels
Therefore, while existing evidence supports low local toxicity, comprehensive in vitro and in vivo immunogenicity testing remains advisable prior to clinical translation [71, 191]
