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In a trial of 1,961 adults conducted over 68 weeks, only 4.5% of those taking semaglutide discontinued the medications due to side effects, so both medications are safe for use, including in the long term
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Semaglutide and tirzepatide share two common substitutions, one is Aib at the second N-terminal residue and the other is acylated lysine at the 20 th N-terminal residue by C18 diacid via a Glu-2OEG linker, to reduce degradation by dipeptidyl peptidase-4 (DPP-4) and to prolong their half-lives by enhanced binding to plasma albumin (Fig
