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proposed in 1906 that the duodenal mucosa might secrete a hormonal substance, which would affect the disposal of glucose from the blood by acting as a chemical excitant for the internal secretion of the pancreas and tried to treat diabetes (not very successfully) by injections of gut extracts ( As already briefly alluded to, the incretin effect in its strict sense is quantified by performing an oral glucose tolerance test (typically with 75 g of glucose in healthy individuals

Furthermore, Liu et al

That is the sensation that you get with GLP1 therapies and it is experienced by about 10-20% of people but the vast majority of these symptoms settle after around about 8-12 weeks in most people and if somebody were in a situation where they felt nauseated there is no reason that they need to escalate from 0.25mg up to 0.5mg until that nausea has settled

These can include nausea, vomiting, diarrhea, constipation, abdominal discomfort, reduced appetite, and reflux

The more common side effects are gastrointestinal, such as nausea and vomiting

The increase in ROS levels activates the transcriptional factor NF-B, leading transactivation of the viral genes and inducing the transcription of viral proteins [12]