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In parallel, a failure in the antioxidant mechanism would occur, disrupting cell homeostasis and culminating in cell damage.52 Melanocytes cultured from unaffected areas in patients with vitiligo have a greater susceptibility to oxidative stress than from controls without vitiligo, demonstrating an overall susceptibility of the patient with vitiligo to oxidative damage.53 There is an increase in the superoxide dismutase enzyme (responsible for degrading the O2 radical into H2O2 and O2), an increase in lipid peroxidation (secondary to OS), in addition to a reduction in the catalase enzyme (which converts H2O2 into H2O and O2) in vitiligo
Oxidation, anti-aging & improving skin problems such as darkening, pigmentation, darkening, dullness,
Neurological research has explored its effects in models of traumatic brain injury and spinal cord compression, with several studies reporting improved functional recovery versus vehicle controls
3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship
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The final step in the synthesis of glutathione is the linkage of the dipeptide gamma-glutamyl-cysteine with glycine by the action of glutathione synthetase
