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The ATTAIN global phase 3 registration program demonstrated clinically significant and meaningful body weight reduction along with improvements in markers of cardiometabolic disease, such as waist circumference, blood pressure, lipids and highsensitivity Creactive protein, in people with obesity, with and without type 2 diabetes, with an efficacy and safety profile generally similar to injectable incretin-based OMMs 3,9
Assessment: melanocyte activity in vitro, in vivo melanogenesis in several model organisms (Xenopus frog, lizard, mouse)
PMID 727443
And even when you can find them, theres the separate issue of affordability
Most reactions are mild and resolve on their own within a few days to weeks
Even so, tirzepatide delivered up to 15.7% body weight loss in this more challenging population
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