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Clinically supervised topical use, with pharmaceutical-grade formulations, is the safest approach

Desensitization involves slowly introducing the medication at low doses until an effective dose is reached and tolerated

Most treatments are designed to reduce hyperpigmentation , such as melasma, acne marks, or sun spots, rather than whiten naturally healthy skin

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VEGF is an angiogenic growth factor that participates in promoting angiogenesis and vascular permeability in both physiological and pathological processes