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Impairment of fertility Studies in which male and female rats received twice daily subcutaneous doses lixisenatide of 2, 29, or 414 mcg/kg prior to pairing through gestation day 6 did not indicate any adverse effects on male or female fertility in rats up to the highest dose tested, 414 mcg/kg, or approximately 400-times the clinical systemic exposure at 20 mcg/day based on mcg/m2
Brayden DJ, Hill TA, Fairlie DP, Maher S, Mrsny RJ (2020) Systemic delivery of peptides by the oral route: formulation and medicinal chemistry approaches
Does insurance cover semaglutide for microdosing
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Participants with prior GLP-1RA prescriptions had average AUDIT-C scores approximately 8% lower than those in the future-prescription group, although the difference was not statistically significant
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