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This transcription factor activates pro-survival pathways, induces epithelial mesenchymal transition (EMT), and upregulates drug efflux pumps, thereby promoting drug resistance
Iron levels in lung tissue Fresh lung tissue was homogenized in 1 mL of PBS
Placebo-controlled, randomized trial of the addition of once-weekly glucagon-like peptide-1 receptor agonist dulaglutide to titrated daily insulin glargine in patients with type 2 dia-betes (AWARD-9)
Relevant biomarkers include fasting insulin, HbA1c, lipid panels, inflammatory markers (hsCRP), and liver function tests
Obesity-associated leptin dysregulation also alters alveolar macrophage activity and leukotriene production, which may explain why obese asthmatics respond differently to corticosteroids but benefit from leukotriene modifiers
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