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Heslehurst N, Vieira R, Akhter Z, Bailey H, Slack E, Ngongalah L, et al

The HPA axis normally triggers cortisol release during stress, but chronic activation leads to elevated baseline cortisol, which is linked to weight gain, inflammation, and metabolic dysfunction

[8] detoxification of acyl groups by forming acylcarnitine, which is then excreted to prevent the accumulation of potentially toxic fatty acyl intermediates

The cost of that breadth is that it leans on mechanism and individual trials rather than a single combination headline

Visible blood in urine may require urgent referral under NICE suspected cancer guidelines (NG12)

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