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LR3 IGF-1 binds poorly to IGF binding proteins (IGFBPs), giving it a circulating half-life of roughly 20-30 hours versus minutes for native IGF-1 (Tomas et al., 1993)

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Starting above 0.25 mg is technically off-label but is commonly used in specialist obesity and endocrinology practice for patients transitioning from another GLP-1 medication

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If youre worried about regaining weight after stopping Ozempic, having a plan to maintain a healthy lifestyle during this transition can help