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Pathobiology of the Klotho Antiaging Protein and Therapeutic Considerations
Previous studies in mouse models have demonstrated that MC4R deficiencyparticularly when combined with MC3R or LDL-receptor lossexacerbates metabolic disturbances, resulting in marked hypercholesterolemia with elevated LDL and very low-density lipoprotein fractions, as well as triglycerides, thereby fostering a pro-atherogenic lipid profile [94, 95]
doi:10.2174/157340313805076322
Background: Pigmented entities are relatively common in the oral mucosa and arise from intrinsic and extrinsic sources
For decades, its physiological relevance remained speculative, as the peptide had not yet been identified in human tissue
F.SaleemM
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