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This condition primarily arises from an imbalance between muscle protein synthesis and degradation, alongside reduced force-generating capacity, often secondary to neuropathy, myofibrillar disruption, sarcoplasmic reticulum (SR) impairment, altered excitability and mitochondrial dysfunction (68)

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While the benefits of the weight loss associated with GLP-1 agonist therapy can no longer be denied, it remains the case that a significant amount of that weight loss comes from loss of muscle

You can also use ice but wrapped in cloth, not applied directly to the skin

However, this same mechanism may contribute to gastrointestinal side effects, which are among the most commonly reported adverse reactions with GLP-1 therapy

Consulting with a healthcare professional is crucial for personalized recommendations based on individual needs and fitness goals