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Their primary therapeutic actions include stimulating glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying to promote satiety, and acting on hypothalamic appetite centers to reduce hunger and caloric intake

In addition, GLP-1 indirectly inhibits glucagon secretion by stimulating release of insulin and somatostatin or by directly engaging with GLP-1R found on cells of the pancreas (2)

2) Applications: - Anti-wrinkle serums, eye creams (targeting nasolabial folds, crows feet)

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2023 May;29(5):569-575