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This GHR upregulation sensitises local cells to circulating GH, potentiating GH-induced JAK2/STAT signalling and stimulating collagen matrix synthesis, IGF-1 production, and fibroblast proliferation providing a mechanism through which BPC-157 engages the GH/IGF-1 axis at the tissue level without altering systemic GH secretion

10.1074/jbc.R111.283432 J

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As CHAC1 is found predominantly in higher eukaryotes, most other species possess only the CHAC2 homolog