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In activated lymphocytes, IL-12 upregulates DPP4 translation whereas TNF decreases cell surface expression, which might be due to elevated sDPP4 release (22)

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Interestingly, although most of the organoids were derived from biopsies taken during routine follow-up, the organoid budding rate showed a significant negative correlation with the endoscopic scores at the time of initial diagnosis, but no significant correlation with the clinical symptom scores or endoscopic scores during follow-up, nor with the clinical symptom scores at the time of initial diagnosis (Fig