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Aims and hypotheses Primary aim The primary aim is to test the hypothesis that treatment with 400 mg per day of oral SAMe for 180 days will lead to a greater reduction from baseline plasma levels of p-tau181 compared to placebo in patients with mild cognitive impairment or dementia due to AD
They are metabolic restoration drugs whose effects extend to cardiovascular disease, kidney disease, neurodegeneration, osteoarthritis, and systemic inflammation
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Beyond the obesity indication, they are studying retatrutide for type 2 diabetes (TRIUMPH-2), obstructive sleep apnea (TRIUMPH-3), and cardiovascular outcomes
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