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F., Lingvay, I., & STEP 1 Study Group
Your healthcare team can also evaluate whether the benefits of continuing GLP-1 therapy outweigh the discomfort, or whether alternative diabetes or weight management strategies should be considered
High levels of cytoplasmic tyramine result in its transport into vesicles via VMAT2, displacing stored vesicular norepinephrine into the neuronal cytoplasm, resulting in an increase of cytoplasmic norepinephrine (Raiteri and Levi, 1986
But its important to know you have other, less invasive options
Considering their mechanism of action, there is a rationale for using GLP-1 agonists in conditions such as dumping syndrome to slow gastric emptying, diarrhoea-dominant IBS, bile acid diarrhoea due to their potentiation of the ileal brake mechanism18 or even short bowel syndrome and high output stomas.19 These are currently not licensed indications nor have any trials been undertaken to date
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