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They are generally avoided in people with a personal or family history of medullary thyroid cancer or MEN2 syndrome, a history of pancreatitis, severe gastroparesis, or during pregnancy and breastfeeding, and they require caution in significant kidney or liver disease
The reconstitution volume also differs: the combo vial uses 2mL of bacteriostatic water rather than 2.5mL, so the unit-to-milligram conversion changes
Trials vary by which molecule they use, what dose they give, and what population they study
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95%CI: 0.99-1.31] compared to subjects with the lowest GGT activity
Conversely, additional diagnoses of hypertension or high cholesterol did not increase GLP-1 initiation rates
