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Some molecules cross directly through cells via transcellular transport
In rabbit studies with 0.8 cm radial bone defects that remained incompletely healed in all control animals for 6 weeks, BPC-157 treatment (administered locally into the bone defect or intramuscularly) produced healing comparable to standard treatments including local bone marrow application or autologous cortical bone grafting
Human side-effect rates and interaction risks are not established
However, exclusive use of folic acid in treating vitamin B12 deficient megaloblastic anemia could result in progressive and irreversible neurologic damage
Bioactivity was determined using an IGF-1-responsive firefly luciferase reporter assay
After 28 days, potency degradation accelerates beyond acceptable limits
