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10.1186/s10020019-01025 Summary Keywords environmental agents, autoimmune diseases, microbiome, oxidative stress, dysbiosis Citation Khan MF and Wang H (2020) Environmental Exposures and Autoimmune Diseases: Contribution of Gut Microbiome
(Waldner 2006) A double-blind RCT (n=30) in patients receiving high-dose interleukin-2 therapy reported a reduction in serious cardiac events (e.g., arrhythmias and acute heart failure) with L-carnitine use compared to no therapy, but the small sample size and heterogeneity of the cancer types limit generalizability
Post-translational modification of RNA m6a demethylase alkbh5 regulates ros-induced DNA damage response
L-carnitine activates the AKT/FOXO3a/MaFbx pathway, increases p70S6k protein expression, and promotes p-p70S6k phosphorylation to ameliorate the muscle wasting of cancer cachexia in CT26-bearing mice In our in vivo study, p-Akt and p-FOXO3a were decreased in CT26 tumor-bearing mice, and FOXO3a and MAFbx were increased, which could partly explain the muscle loss in the cachectic mice (Fig
However, relying exclusively on liquid nutrition long-term is not ideal, as chewing solid food helps with satiety signaling and nutrient absorption
These results are consistent with results observed in mice (26) and strongly support a role for gut microbiota in BB generation from dietary l-carnitine in humans
