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They typically resolve or become manageable within 2-4 weeks at each new dose level

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While these transporters are expressed in various tissues, their expression is especially important in the small intestine, liver, kidneys and blood-brain barrier, because drug transporters play an essential role in the absorption, distribution and excretion in these tissues

Injection site reactions Redness, swelling, or itching at injection sites occurs in some individuals

Some patients need both, some just one