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Interestingly, systems regulating the circulation of brain extracellular fluid and cerebrospinal fluid, such as the glymphatic system, are also decreased with healthy aging [53, 100]

This reduces the amount that would get stored otherwise, improving the results of diet and exercise

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In the Morris Water Maze (MWM), spatial learning was markedly disrupted in the STZ group, as reflected by prolonged escape latencies, while the performance of the STZR and R groups remained comparable to that of controls

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